1005828 合理的創薬は可能か?

Molecular-based drug discovery

Structure-based drug design (one drug, one target)
Database-used in silico screening (one drug, all target)??
●Molecular-based drug discovery
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Nature 1990 vol 347, pp645
Ligand binding and co-activator assembly of the peroxisome prolifertor-activated receptor-gamma
Nature 1998, vol 397, pp137
●Structure-based drug design (one drug, one target)
立体構造をもとにSelectivityを高めることQ-SAR戦略。
しかし、Lead compoundによる制約。
→ 化合物ライブラリーからLead compoundをスクリーニング。
Flagment-based drug discovery, FBDD
Q-SAR + FBDD しかし、ほとんどがphase I
副作用が問題
●Database-used in silico screening (one drug, all target)??
Predicting new molecular targets for known drugs
Nature (2009),462,pp175
Comprehensive Structural Classification of Ligand-Binding Motifs in Proteins
Structure (2009), 17, pp234
Q-SAR + FBDD => Higher selectivity
               ↓
Database screening => Lower side-effect
関連記事
Count per Day
    Popular Posts
    スポンサーリンク

    シェアする

    • このエントリーをはてなブックマークに追加

    フォローする